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The pipecolate location of rapamycin composition would seem necessary for rapamycin-binding to FKBP12. This stage is needed for further binding of rapamycin towards the mTOR kinase, that's The real key enzyme in many Organic steps of rapamycin.[46] [15] The inhibition of the PI3K/mTOR pathway has become shown to potently block https://johnu099qja0.iyublog.com/profile

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