Gastrointestinal (GI): NSAIDs that block COX-one action have correlations with GI problems a result of the inhibition on the synthesis of gastroprotective agents for example PGE2 and also other prostaglandins. This inhibition contributes to reduced mucin generation by gastric epithelial cells, considerably less bicarbonate secretion, and less epithelial mobile turnover, https://davido011byv9.digitollblog.com/profile