Less than conditions of very low CB1R density, THC antagonises endogenous agonists possessing larger receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which can deliver more oblique routes for altering dopamine transmission21. Also, THC has psychoactive metabolites with CB1R affinity, further complicating the analyses of receptor binding studies22. https://rafaelgoswz.blogaritma.com/31369998/the-best-side-of-cannabis