Pentobarbital will reduce the extent or influence of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. pentobarbital will lower the level or impact of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known. pentobarbital will decrease the level or impact of acalabrutinib by influencing hepatic/intestinal enzyme... https://sodiumpentobarbital17901.full-design.com/the-2-minute-rule-for-nembutal-pentobarbital-100mg-77101785