There exists a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to lessen afferent soreness transmission and generate analgesia. As a result, medicine like clonidine that target alpha-2 receptors can affect the transmission of soreness. This information is just not https://www.proleviate.com/post/the-new-pain-killer-conolidine