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Respiratory depression is among the most feared adverse effect of opioids — along with the primary reason behind opioid-associated death. Tramadol’s ceiling effect on μ-opioid receptor activation boundaries the extent to which it can suppress respiration, even at supratherapeutic doses. This pharmacological ceiling can make it noticeably safer in both https://buyzopicloneonline72356.review-blogger.com/59616999/how-buy-dihydrocodeine-online-can-save-you-time-stress-and-money

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